Apathologist,Dr.WarrenChapin(playedbyVincentPrice),discoversthatthetinglingofthespineinstatesofextremefearisduetothegrowthofa"tingler"—aspinalparasitewhichcankillthehostunlessitisdestroyedbyscreaming.

迈克是一名职业演员，为筹集八千元制作费，男扮女装应聘到电视台扮演剧中医院院长杜奇。杜奇以出色表演很快走红，男扮女装的杜奇引来了追求者，闹出了许多笑话。杜奇与女演员朱丽在相处中，渐渐爱上了朱丽，在剧目实播时，迈克当众换掉女…